A palladium‐catalyzed asymmetric [4 + 3] cycloaddition of trimethylenemethanes and indoline‐derived aza‐dienes has been developed. The potential [3 + 2] side pathway was completely suppressed in the process. This protocol provides an efficient access to azepino[2,3‐b]indoles bearing two vicinal stereocenters in generally excellent diastereo‐ and enantioselectivities (up to > 20 : 1 dr, 99% ee).

中文翻译：

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通过钯催化的[4 + 3]环加成反应对Azepino [2,3-b]吲哚进行高度区域，非对映和对映选择性组装†

已经开发了钯催化的不对称[4 + 3]环丁烷与亚吲哚啉衍生的氮杂二烯的环加成反应。在此过程中，潜在的[3 + 2]旁通路被完全抑制。这个协议提供了氮杂并[2,3-一个有效的访问b〕吲哚轴承两个邻位立体中心在大致优良diastereo-和对映选择性（高达> 20：1个博士，99％ee）的。