Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double-blind, placebo-controlled study.,Neurogastroenterology & Motility

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Human milk oligosaccharide supplementation in irritable bowel syndrome patients: A parallel, randomized, double-blind, placebo-controlled study.
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2020-06-14 , DOI: 10.1111/nmo.13920
Cristina Iribarren _{1,

2} , Hans Törnblom ₂ , Imran Aziz _{2,

3} , Maria K Magnusson ₁ , Johanna Sundin ₂ , Louise K Vigsnaes ₄ , Ingvild Dybdrodt Amundsen ₄ , Bruce McConnell ₄ , Dorthe Seitzberg ₄ , Lena Öhman _{1,

2} , Magnus Simrén _{2,

5}

Affiliation

Human milk oligosaccharides safely and beneficially impact bifidobacteria abundance in healthy adults, while their effects in patients with irritable bowel syndrome (IBS) are unknown. Hence, we aimed to determine the dose of 4:1 mix of 2’‐O‐fucosyllactose and Lacto‐N‐neotetraose (2’FL/LNnT) that increases fecal bifidobacteria abundance without aggravating overall gastrointestinal symptoms in IBS patients in a randomized, double‐blind, controlled study. Additionally, the impact of 2’FL/LNnT on the fecal bacterial profile was assessed.

中文翻译：

肠易激综合征患者补充母乳寡糖：一项平行、随机、双盲、安慰剂对照研究。

人乳寡糖安全且有益地影响健康成人的双歧杆菌丰度，而它们对肠易激综合征 (IBS) 患者的影响尚不清楚。因此，我们旨在确定 2'-O-岩藻糖基乳糖和乳-N-新四糖 (2'FL/LNnT) 的 4:1 混合剂量，在随机、双盲、对照研究。此外，还评估了 2'FL/LNnT 对粪便细菌谱的影响。

更新日期：2020-06-14

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