The marine bacterium Vibrio natriegens is the fastest‐growing non‐pathogenic bacterium known to date and is gaining more and more attention as an alternative chassis organism to Escherichia coli. A recent wave of synthetic biology efforts has focused on the establishment of molecular biology tools in this fascinating organism, now enabling exciting applications – from speeding up our everyday laboratory routines to increasing the pace of biotechnological production cycles. In this review, we seek to give a broad overview on the literature on V. natriegens, spanning all the way from its initial isolation to its latest applications. We discuss its natural ecological niche and interactions with other organisms, unveil some of its extraordinary traits, review its genomic organization and give insight into its diverse metabolism – key physiological insights required to further develop this organism into a synthetic biology chassis. By providing a comprehensive overview on the established genetic tools, methods and applications we highlight the current possibilities of this organism, but also identify some of the gaps that could drive future lines of research, hopefully stimulating the growth of the V. natriegens research community.

中文翻译：

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纳特里根弧菌：一种超快速生长的海洋细菌，作为新兴的合成生物学基础。

海洋细菌弧菌是迄今为止已知的生长最快的非致病性细菌，并且作为大肠杆菌的替代底盘生物体而受到越来越多的关注。最近一波合成生物学工作的重点是在这种迷人的生物体中建立分子生物学工具，现在可以实现令人兴奋的应用——从加快我们的日常实验室常规到加快生物技术生产周期的步伐。在这篇综述中，我们试图对V. natriegens的文献进行广泛的概述，从最初的隔离一直到最新的应用。我们讨论其自然生态位以及与其他生物体的相互作用，揭示其一些非凡特征，回顾其基因组组织并深入了解其多样化的新陈代谢——进一步将该生物体发展成合成生物学底盘所需的关键生理学见解。通过对已建立的遗传工具、方法和应用进行全面概述，我们强调了这种生物体当前的可能性，同时也确定了一些可能推动未来研究方向的差距，有望刺激V. natriegens研究界的发展。