Eukaryotic genomes generate vast numbers of non-protein-coding RNAs (ncRNAs) that can inhibit mRNA synthesis through transcription interference, but the mechanisms are unclear. Gill et al. show that transcription of antisense ncRNAs induces ‘elongation marks’ on histones in promoter regions. These inhibit active nucleosome positioning required to maintain open transcription-initiation sites.

中文翻译：

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扩展的ncRNA干扰启动子核小体动力学。

真核基因组会产生大量的非蛋白质编码RNA（ncRNA），它们可以通过转录干扰抑制mRNA的合成，但其机制尚不清楚。吉尔等。结果表明反义ncRNA的转录在启动子区域的组蛋白上诱导了“延伸标记”。这些抑制维持开放的转录起始位点所需的活性核小体定位。