Guy Alexandre made major contributions to organ transplantation that, in my opinion, have not been sufficiently recognized by the transplant community. To make his contributions better known, I present a brief summary of the innovations for which he was largely responsible. As a research fellow at the Peter Bent Brigham Hospital in Boston in 1962–3, under subsequent Nobelist Joseph Murray, he contributed to the establishment of pharmacologic immunosuppressive therapy (initiated by Roy Calne) in patients undergoing renal allotransplantation. After his return to his native Belgium, he carried out the first clinical kidney transplant there and, controversially, was the first to take kidneys from brain-dead donors (in 1963), a major advance in organ transplantation. He was also the first to carry out an elective series of kidney transplants between ABO blood group-incompatible donors and recipients, using pre-transplant plasmapheresis to deplete anti-A/B antibodies. This led him to explore kidney xenotransplantation, reporting prolongation of function of pig kidneys in baboons in 1989. Finally, in the early 1990s, he investigated the concept of thymic tissue transplantation as a means of inducing tolerance to donor-specific allografts. I hope this summary of his work makes his pioneering contributions better known to the transplant community.

盖伊·亚历山大（Guy Alexandre）为器官移植做出了重大贡献，我认为，器官移植还没有得到足够的认可。为了更好地了解他的贡献，我简要介绍了他主要负责的创新。1962–3年，在波士顿的彼特·本特·百翰医院做研究员，随后成为诺贝尔奖获得者约瑟夫·默里（Joseph Murray），他为建立接受肾脏同种异体移植的患者建立药物免疫抑制疗法（由罗伊·卡恩发起）做出了贡献。回到他的家乡比利时后，他在那进行了第一例临床肾脏移植，并且有争议的是，他是第一个从脑死亡捐献者那里摘取肾脏的器官（1963年），这是器官移植的一项重大进展。他也是第一位在不适合ABO血型的供血者和接受者之间进行选择性肾脏移植的系列活动，使用移植前血浆置换术消耗抗A / B抗体。这导致他探索了肾脏异种移植，并于1989年报告了狒狒中猪肾脏功能的延长。最后，在1990年代初期，他研究了胸腺组织移植的概念，以诱导对供体特异性同种异体移植的耐受性。我希望他的工作总结能使移植界更加了解他的开拓性贡献。他研究了胸腺组织移植的概念，以诱导对供体特异性同种异体移植的耐受性。我希望他的工作总结能使移植界更加了解他的开拓性贡献。他研究了胸腺组织移植的概念，以诱导对供体特异性同种异体移植的耐受性。我希望他的工作总结能使移植界更加了解他的开拓性贡献。