Abstract Low scattering media is the best scenario for optical imaging in thick samples and deep tissue, as it allows to obtain high resolution images without suffering the limitations that the diffusion phenomenon imposes. The high contribution of ballistic light in this regime enabled the development of light sheet microscopy and optical projection tomography, two of the most common techniques nowadays in research laboratories. Their revolutionary approach and wide spectrum of applications and possibilities has lead to a frenetic rhythm of new works and techniques arising every year. The large amount of information available often overwhelms scientists and researchers trying to keep up to date with the last cutting edge advances of the field. This paper aims to give a brief review of the origins and fundamental aspects of these two techniques to focus on the most recent and yet non reviewed works. Apart from novel methods, this document also covers combined multimodal approaches and systems. To conclude, we put a spotlight on the important role that open-source microscopy systems play in the field, as they improve the accessibility to these techniques and promote collaborative networks across the optical imaging community.

中文翻译：

---

低散射介质中光学断层扫描的最新进展

摘要 低散射介质是厚样品和深层组织中光学成像的最佳方案，因为它可以获得高分辨率图像而不受扩散现象的限制。弹道光在这种情况下的巨大贡献促进了光片显微镜和光学投影断层扫描的发展，这是当今研究实验室中最常见的两种技术。他们的革命性方法和广泛的应用范围和可能性导致了每年都会出现的新作品和技术的狂热节奏。大量可用信息常常让试图跟上该领域最新前沿进展的科学家和研究人员不知所措。本文旨在简要回顾这两种技术的起源和基本方面，重点关注最新但尚未审查的作品。除了新颖的方法外，本文档还涵盖了组合多模式方法和系统。总之，我们将重点放在开源显微镜系统在该领域发挥的重要作用上，因为它们提高了这些技术的可访问性并促进了整个光学成像社区的协作网络。