Abstract A non-enzymatic electrochemical sensor based on cuprous oxide nanocubes (Cu2O-NC) has been developed. Cu2O-NC samples have been synthesized using a wet precipitation technique under different precipitation temperatures (25 and 60 °C). The samples were characterized by XRD (X-ray Diffraction), UV–visible Diffuse Reflectance Spectroscopy (UV–Vis DRS) and Scanning Electron Microscopy (SEM). Screen-printed carbon electrodes (SPCE) have been modified by casting the synthesized Cu2O-NC. The fabricated Cu2O-NC-SPCE sensor prepared at 25 °C provided the best sensing performance toward glucose, with a sensitivity of 1040 μA/mM cm−2 in the linear range from 0.007 to 4.5 mM, and a detection limit of 3.1 μM (S/N = 3). Cu2O-NC-SPCE electrodes were also evaluated for the amperometric determination of glucose. Testing results showed a satisfactory stability toward glucose sensing and selectivity against other sugars and ethanol, suggesting that the SPCE modification with Cu2O-NC could be a simple way to fabricate inexpensive and reliable sensors to monitor glucose in bio-fermentation processes.

中文翻译：

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基于Cu2O纳米立方体的非酶促丝网印刷传感器用于生物发酵过程中的葡萄糖测定

摘要 开发了一种基于氧化亚铜纳米立方体（Cu2O-NC）的非酶电化学传感器。Cu2O-NC 样品是在不同的沉淀温度（25 和 60 °C）下使用湿法沉淀技术合成的。通过 XRD（X 射线衍射）、紫外-可见漫反射光谱（UV-Vis DRS）和扫描电子显微镜（SEM）对样品进行表征。通过浇铸合成的 Cu2O-NC 对丝网印刷碳电极 (SPCE) 进行了改进。在 25 °C 下制备的 Cu2O-NC-SPCE 传感器对葡萄糖的传感性能最好，灵敏度为 1040 μA/mM cm-2，线性范围为 0.007 至 4.5 mM，检测限为 3.1 μM（信噪比 = 3)。Cu2O-NC-SPCE 电极也用于葡萄糖的电流测定。