Whey protein, a by-product of cheese industry, is harmful for the environment (i.e., surface and subterranean waters, soil) and, therefore, for humans due to its high polluting burden. Concomitantly, it has been reported that it is a mixture with potent antioxidant action since it is rich in cysteine residues, which are necessary for glutathione synthesis in vivo. On this basis, this study intended to examine the role of whey protein on the intensification of tissue antioxidant arsenal. To this end, a dose of sheep/goat whey protein equal to 1 g/kg of body weight/day dissolved in drinking water was administered to rats for 28 consecutive days. According to our findings, whey protein improved the antioxidant profile of liver, small intestine, lung and muscle whereas it did not affect the redox state of kidney. Our results were based on the alterations found in the protein expression of glutamate cysteine ligase, catalase and superoxide dismutase-1 measured in all tissues and the activity of glutathione S-transferase evaluated in muscle. Although tissue-specific, it is obvious that the action of whey protein is biologically beneficial and could serve as a biofunctional constituent for foods able to improve redox profile when administered against redox-related diseases.

乳清蛋白是干酪工业的副产品，由于其高污染负担，因此对环境（即地表和地下水域，土壤）有害，因此对人类有害。伴随地，据报道它是具有强抗氧化作用的混合物，因为它富含半胱氨酸残基，这对于体内谷胱甘肽合成是必需的。。在此基础上，本研究旨在检验乳清蛋白在组织抗氧化剂阿森纳强化中的作用。为此，连续28天向大鼠施用等于1g / kg体重/天的饮用水中溶解的绵羊/山羊乳清蛋白剂量。根据我们的发现，乳清蛋白可改善肝脏，小肠，肺和肌肉的抗氧化特性，而不会影响肾脏的氧化还原状态。我们的结果基于在所有组织中检测到的谷氨酸半胱氨酸连接酶，过氧化氢酶和超氧化物歧化酶-1的蛋白质表达的变化以及在肌肉中评估的谷胱甘肽S-转移酶的活性。尽管是组织特异性的