The study aimed to investigate association of circulating leptin, adiponectin, chemerin, and omentin-1 with metabolic syndrome (MetS) and cardio-metabolic risk factors in youths. Thirty eight young males were enrolled. Participants underwent anthropometric and blood pressure measures, and fasting blood sampling. Plasma leptin, adiponectin, chemerin, omentin-1 and insulin were measured by ELISA methods. Multiple linear regression models, adjusting for age, MetS traits, C-reactive protein (CRP) and homeostasis model assessment of insulin resistance (HOMA-IR), were applied to determine correlates for each adipokine. Eleven participants meet criteria of MetS. These individuals had higher leptin and chemerin and lower adiponectin plasma concentrations than those without MetS. Plasma leptin and chemerin were positively related, and adiponectin and omentin-1 were inversely related to cardio-metabolic traits. In multivariate models, predictors of leptin were age (β, 0.20, P = 0.01), abdominal obesity (β, 0.24, P = 0.06), raised blood pressure (β, 0.40, P = 0.01), raised triglycerides (β, 0.19, P = 0.01) and CRP (β, 0.31, P = 0.01). Chemerin was associated with abdominal obesity (β, 0.33, P = 0.09) and CRP (β, 0.29, P = 0.04), and adiponectin was associated with raised triglycerides (β, -0.26, P = 0.05), decreased HDL-C (β, -0.28, P = 0.06) and CRP (β, -0.48, P = 0.01). HOMA-IR (β, -0.39, P = 0.09) was the only predictor for omentin. MetS is associated with an altered plasma adipokines profile, with increased leptin and chemerin and decreased adiponectin circulating levels. These findings suggest a beneficial potential of adiponectin and omentin, but a detrimental potential of leptin and chemerin. Further research is needed to lighten the role of adipose tissue-derived adipokines in cardio-metabolic health.

中文翻译：

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选定的脂肪因子与年轻男性代谢综合征和心脏代谢危险因素的关联

该研究旨在调查循环瘦素、脂联素、chemerin 和 omentin-1 与青少年代谢综合征 (MetS) 和心脏代谢危险因素的关联。三十八名年轻男性被录取。参与者接受了人体测量和血压测量，以及空腹采血。通过ELISA方法测量血浆瘦素、脂联素、chemerin、omentin-1和胰岛素。应用多元线性回归模型，调整年龄、MetS 特征、C 反应蛋白 (CRP) 和胰岛素抵抗的稳态模型评估 (HOMA-IR)，以确定每种脂肪因子的相关性。11 名参与者符合 MetS 的标准。这些个体比没有 MetS 的个体具有更高的瘦素和凯莫瑞，以及更低的脂联素血浆浓度。血浆瘦素和凯莫瑞呈正相关，脂联素和 omentin-1 与心脏代谢特征呈负相关。在多变量模型中，瘦素的预测因子是年龄 (β, 0.20, P = 0.01)、腹部肥胖 (β, 0.24, P = 0.06)、血压升高 (β, 0.40, P = 0.01)、甘油三酯升高 (β, 0.19 , P = 0.01) 和 CRP (β, 0.31, P = 0.01)。Chemerin 与腹部肥胖 (β, 0.33, P = 0.09) 和 CRP (β, 0.29, P = 0.04) 相关，脂联素与甘油三酯升高 (β, -0.26, P = 0.05)、HDL-C 降低有关 ( β, -0.28, P = 0.06) 和 CRP (β, -0.48, P = 0.01)。HOMA-IR (β, -0.39, P = 0.09) 是网膜蛋白的唯一预测因子​​。MetS 与血浆脂肪因子谱的改变有关，瘦素和凯莫瑞增加，脂联素循环水平降低。这些发现表明脂联素和网膜素具有有益的潜力，但瘦素和凯莫瑞的有害潜力。需要进一步研究以减轻脂肪组织来源的脂肪因子在心脏代谢健康中的作用。