Elevated expression of the cysteine protease Cathepsin S has been correlated with a number of different cancer types in recent years. As tools have been developed to enable more accurate examination of individual cathepsin species, our knowledge and appreciation of the role that this protease plays in facilitating cancer has increased exponentially. This review focuses on our current understanding of the role of Cathepsin S within tumours and the surrounding microenvironment. While various publications have shown that Cathepsin S can be derived from tumour cells themselves, a plethora of more recent studies have identified that Cathepsin S can also be derived from other cell types within the tumour microenvironment including endothelial cells, macrophages and T cells. Furthermore, specific proteolytic substrates cleaved by Cathepsin S have also been identified which have reinforced our hypothesis that this protease facilitates key steps within tumours leading to their invasion, angiogenesis and metastasis.

近年来，半胱氨酸蛋白酶组织蛋白酶 S 的表达升高与许多不同的癌症类型相关。随着工具的开发能够更准确地检查单个组织蛋白酶种类，我们对这种蛋白酶在促进癌症中所起的作用的认识和认识呈指数增长。这篇综述的重点是我们目前对组织蛋白酶 S 在肿瘤和周围微环境中的作用的理解。虽然各种出版物表明组织蛋白酶 S 可以来源于肿瘤细胞本身，但最近的大量研究表明，组织蛋白酶 S 也可以来源于肿瘤微环境中的其他细胞类型，包括内皮细胞、巨噬细胞和 T 细胞。此外，