Background

Nuclear poly(ADP-ribose) polymerase-1 (PARP-1) is a well characterised protein that accounts for the majority of PARylation reactions using NAD⁺ as a substrate, regulating diverse cellular functions. In addition to its nuclear functions, several recent studies have identified localization of PARP-1 in mitochondria and emphasized its possible role in maintaining mitochondrial homeostasis. Various reports suggest that nuclear PARP-1 has been implicated in diverse mitochondria-specific communication processes.

Scope of review

The present review emphasizes on the potential role of PARP-1 in mitochondrial processes such as bioenergetics, mtDNA maintenance, cell death and mitophagy.

Major conclusions

The origin of mitochondrial PARP-1 is still an enigma; however researchers are trying to establish the cross-talk between nuclear and mitochondrial PARP-1 and how these PARP-1 pools modulate mitochondrial activity.

General Significance

A better understanding of the possible role of PARP-1 in mitochondrial homeostasis helps us to explore the potential therapeutic targets to protect mitochondrial dysfunctions.

中文翻译：

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PARP-1在线粒体内稳态中的作用。

背景

核聚（ADP-核糖）聚合酶-1（PARP-1）是一种特征明确的蛋白质，占了使用NAD ⁺作为底物调节多种细胞功能的大部分PARylation反应的蛋白质。除了其核功能外，最近的一些研究还确定了PARP-1在线粒体中的定位，并强调了其在维持线粒体内稳态中的可能作用。各种报告表明，核PARP-1与多种线粒体特异的通讯过程有关。

审查范围

本综述强调了PARP-1在线粒体过程中的潜在作用，例如生物能学，mtDNA维持，细胞死亡和线粒体吞噬。

主要结论

线粒体PARP-1的起源仍是一个谜。然而，研究人员正在尝试建立核和线粒体PARP-1之间的串扰，以及这些PARP-1池如何调节线粒体活性。

一般意义

更好地了解PARP-1在线粒体内稳态中的可能作用，有助于我们探索保护线粒体功能障碍的潜在治疗靶标。