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Memory reconsolidation impairments in sign-tracking to an audiovisual compound stimulus.
Behavioural Brain Research ( IF 2.7 ) Pub Date : 2020-06-15 , DOI: 10.1016/j.bbr.2020.112774
Mohamed L Drame 1 , Maria Balaet 1 , Jonathan L C Lee 1
Affiliation  

Studies of memory reconsolidation of pavlovian memories have typically employed unimodal conditioned stimuli, despite the use of multimodal compound stimuli in other settings. Here we studied sign-tracking behaviour to a compound audiovisual stimulus. First, we observed not unexpectedly that sign-tracking was poorer to the audiovisual compound than to unimodal visual stimuli. Then, we showed that, depending on the parameters of compound stimulus re-exposure at memory reactivation, systemic MK-801 treatment either impaired extinction to improve sign-tracking at test, or disrupted reconsolidation to impair test behaviour. When memory reactivation consisted of re-exposure to only the auditory component of the compound stimulus, we observed sign-tracking impairments following MK-801 treatment, but only under certain test conditions. This was in contrast to the consistent impairment following reactivation with the full audiovisual compound. Moreover, the parameters of auditory stimulus presentation to enable MK-801-induced impairment at test varied depending on whether the stimulus was presented within or outside the training context. These findings suggest that behaviour under the control of appetitive pavlovian compound stimuli can be modulated by targeting both extinction and reconsolidation, and that it is not necessary to re-expose to the full compound stimulus in order to achieve a degree of modulation of behaviour.



中文翻译:

对视听复合刺激进行符号跟踪时的记忆再巩固障碍。

尽管在其他环境中使用了多模态复合刺激,但巴甫洛夫记忆的记忆再巩固研究通常采用单模态条件刺激。在这里,我们研究了复合视听刺激的符号跟踪行为。首先,我们并不意外地观察到符号跟踪对视听化合物的影响比对单峰视觉刺激更差。然后,我们表明,根据记忆重新激活时复合刺激重新暴露的参数,全身性 MK-801 治疗要么损害消退以改善测试时的迹象跟踪,要么破坏再巩固以损害测试行为。当记忆重新激活包括仅重新暴露于复合刺激的听觉成分时,我们观察到 MK-801 治疗后的符号跟踪障碍,但仅在某些测试条件下。这与使用完整视听化合物重新激活后的持续损伤形成对比。此外,在测试中启用 MK-801 诱导损伤的听觉刺激呈现参数根据刺激是在训练环境内还是在训练环境外呈现而有所不同。这些发现表明,在食欲巴甫洛夫复合刺激控制下的行为可以通过针对灭绝和再巩固来调节,并且没有必要重新暴露于完整的复合刺激以实现一定程度的行为调节。在测试中启用 MK-801 诱导损伤的听觉刺激呈现参数根据刺激是在训练环境内还是在训练环境外呈现而变化。这些发现表明,在食欲巴甫洛夫复合刺激控制下的行为可以通过针对灭绝和重新巩固来调节,并且没有必要重新暴露于完整的复合刺激以实现一定程度的行为调节。在测试中启用 MK-801 诱导损伤的听觉刺激呈现参数根据刺激是在训练环境内还是在训练环境外呈现而变化。这些发现表明,在食欲巴甫洛夫复合刺激控制下的行为可以通过针对灭绝和再巩固来调节,并且没有必要重新暴露于完整的复合刺激以实现一定程度的行为调节。

更新日期:2020-06-23
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