Introduction

To investigate the potential prognostic value of image analysis of pelvic bone metastasis in newly diagnosed prostate cancer patients.

Methods

Data from 69 patients with both bone scintigraphy and pelvic CT images were selected for this analysis. Open source software (3D Slicer version 4.8.1.) was used for image analysis. Metastatic pelvic bone lesions were manually contoured, and radiomic features were extracted. As risk factors for overall survival (OS) and cause-specific survival (CSS), 105 radiomic features and clinical risk factors including age, initial prostate-specific antigen, Gleason score, TNM stage, lactate dehydrogenase (LDH), hemoglobin (Hb), alkaline phosphatase, extent of disease, visceral metastases, and radiotherapy were assessed by uni- and multivariate analyses.

Results

Median follow-up was 41 months (range 0–157 months). Five-year overall survival and cause-specific survival rate were 37.9% and 43.5%, respectively. After multivariate analysis, LDH, Hb, and “maximum 2D diameter” defined as maximum tumor size in the axial plane were detected as risk factors for OS. Gleason sum, LDH, and maximum 2D diameter were detected as risk factors for CSS.

Conclusion

Maximum 2D diameter was detected as a significant prognostic factor for metastatic prostate cancer patients.

中文翻译：

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盆腔骨转移的大小是转移性前列腺癌患者的重要预后因素。

介绍

探讨新诊断前列腺癌患者盆腔骨转移影像分析的潜在预后价值。

方法

本次分析选择了 69 名患者的骨闪烁扫描和盆腔 CT 图像数据。开源软件（3D Slicer 版本 4.8.1.）用于图像分析。手动勾勒转移性骨盆骨病变轮廓，并提取影像学特征。作为总生存期 (OS) 和病因特异性生存期 (CSS) 的危险因素，105 个放射组学特征和临床危险因素包括年龄、初始前列腺特异性抗原、格里森评分、TNM 分期、乳酸脱氢酶 (LDH)、血红蛋白 (Hb) 、碱性磷酸酶、疾病程度、内脏转移和放疗通过单变量和多变量分析进行评估。

结果

中位随访时间为 41 个月（范围 0-157 个月）。五年总生存率和病因特异性生存率分别为 37.9% 和 43.5%。经过多变量分析，LDH、Hb 和定义为轴向平面最大肿瘤尺寸的“最大二维直径”被检测为 OS 的危险因素。格里森总和、LDH 和最大二维直径被检测为 CSS 的危险因素。

结论

最大二维直径被检测为转移性前列腺癌患者的重要预后因素。