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Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice.
Stem Cells International ( IF 4.3 ) Pub Date : 2020-06-13 , DOI: 10.1155/2020/9054514
Shune Xiao 1 , Yurong Deng 1 , Xiaojin Mo 1 , Zhiyuan Liu 1 , Dali Wang 1 , Chengliang Deng 1 , Zairong Wei 1
Affiliation  

Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss. However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare. ADSCs exert biological functions via the paracrine actions of various growth factors and cytokines. Conditioned medium from ADSCs (ADSCs-CM) is a cell-free suspension rich in growth factors and cytokines that has demonstrated a significant role in stimulating hair growth, with encouraging outcomes in terms of hair regeneration and hair growth. Extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) is an ADSC- and adipose native extracellular matrix-enriched product for cytotherapy. In this study, we compared the effects of CM from ECM/SVF-gel (ECM/SVF-CM) and from stem cells (SVF-CM) on hair growth in mice. ECM/SVF-CM stimulated hair growth more than SVF-CM, through promoting the proliferation of dermal papilla cells and cells in the bulge, neovascularization, and anagen induction. ECM/SVF-CM might, thus, provide an effective and improved strategy for promoting hair growth. These data provide a theoretical foundation for the clinical administration of ECM/SVF-CM for the treatment of hair loss.

中文翻译:

通过条件培养基从C57BL / 6小鼠的细胞外基质/基质血管分数凝胶促进毛发生长。

基于脂肪的干细胞(ADSC-)再生医学已经扩展到包括脱发的治疗。然而,干细胞疗法仍然是一种相对较新的技术,很少有报道将其用于治疗脱发。ADSC通过各种生长因子和细胞因子的旁分泌作用发挥生物学功能。来自ADSC的条件培养基(ADSCs-CM)是一种富含生长因子和细胞因子的无细胞悬浮液,在刺激毛发生长方面显示出重要作用,在毛发再生和毛发生长方面令人鼓舞。细胞外基质/基质血管分数凝胶(ECM / SVF-gel)是ADSC和脂肪天然细胞外基质富集的产品,用于细胞治疗。在这项研究中,我们比较了ECM / SVF-gel(ECM / SVF-CM)和干细胞(SVF-CM)CM对小鼠毛发生长的影响。ECM / SVF-CM通过促进真皮乳头细胞和凸起中的细胞增殖,新血管形成和毛发生长诱导作用,比SVF-CM更能刺激头发生长。因此,ECM / SVF-CM可能会提供有效且改进的策略来促进头发生长。这些数据为ECM / SVF-CM用于脱发的临床管理提供了理论基础。
更新日期:2020-06-13
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