Introduction

Erectile dysfunction (ED) is defined as the inability to achieve or maintain an erection sufficient for satisfactory sexual performance. It is estimated that 20–30% of adult men will have at least one episode of ED during their lifetime and the prevalence increases with age. ED is known to have significant negative psychological implications for men, resulting in impaired functional status and a greater prevalence of anxiety and depression.

Areas covered

Medications for the treatment of erectile dysfunction largely revolve around oral, injection, and topical therapies. Though all three modalities are widely used, each delivery option has its own advantages and specific indications. Likewise, there are several new developing treatments for ED that may change the landscape of treatment. The goal of this review is to summarize contemporary drug delivery options used in the treatment of ED and highlight future promising pharmacological developments.

Expert opinion

There are a myriad of new developments on the horizon including new PDE5Is and drug targets, nanotechnology enhancements, stem cell and gene therapy, shockwave therapy, and platelet-rich plasma injections. These are all promising new methods to not only treat ED but also to address the pathology and prevent or eliminate further damage.

中文翻译：

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勃起功能障碍管理中的药物输送选择和治疗进展。

介绍

勃起功能障碍（ED）定义为无法实现或维持足以使性行为令人满意的勃起。据估计，成年男性中有20–30％在其一生中至少会发作一次ED，而且患病率会随着年龄的增长而增加。已知ED对男性具有明显的负面心理影响，导致功能状态受损以及焦虑和抑郁的患病率更高。

覆盖区域

治疗勃起功能障碍的药物主要围绕口服，注射和局部疗法。尽管这三种方式都得到了广泛使用，但是每种交付方式都有其自身的优势和具体指示。同样，有几种针对ED的新兴治疗方法可能会改变治疗方法。这篇综述的目的是总结用于治疗ED的当代药物输送方法，并强调未来有希望的药理学发展。

专家意见

即将出现的众多新进展包括新的PDE5I和药物靶标，纳米技术的增强，干细胞和基因疗法，冲击波疗法以及富含血小板的血浆注射剂。这些都是有前途的新方法，不仅可以治疗ED，而且可以解决病理问题并预防或消除进一步的损害。