Inflammation can promote the development of arthritis, obesity, cardiovascular, type II diabetes, pancreatitis, metabolic and neurodegenerative diseases, and certain types of cancer. Compounds isolated from plants have been practiced since ancient times for curing various ailments including inflammatory disorders and to support normal physiological functions. Curcumin (diferuloylmethane) is a yellow coloring agent, extracted from turmeric that has been used for the prevention and treatment of various inflammatory diseases. Numerous studies have shown that curcumin modulate multiple molecular targets and can be translated to the clinics for multiple therapeutic processes. There is compelling evidence that curcumin can block cell proliferation, invasion, and angiogenesis as well as reduced the prolonged survival of cancer cells. Curcumin mediates anti-inflammatory effect through downregulation of inflammatory cytokines, transcription factors, protein kinases, and enzymes that promote inflammation and development of chronic diseases. In addition, curcumin induces apoptosis through mitochondrial and receptor-mediated pathways by activating caspase cascades. Curcumin is a safe and nontoxic drug that has been reported to be well tolerated. Available clinical trials support the potential role of curcumin for treatment of various inflammatory disorders. However, curcumin's efficacy is hindered by poor absorption and low bioavailability, which limit its translation into clinics. This review outlines the potential pharmacological and clinical role of curcumin, which provide a gateway for the beneficial role of plant isolated compounds in treatment of various inflammatory diseases and cancer.

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炎症可促进关节炎、肥胖、心血管、II 型糖尿病、胰腺炎、代谢和神经退行性疾病以及某些类型癌症的发展。从植物中分离出的化合物自古以来就被用于治疗各种疾病，包括炎症性疾病和支持正常的生理功能。姜黄素 (diferuloylmethane) 是一种黄色着色剂，从姜黄中提取，已用于预防和治疗各种炎症性疾病。大量研究表明，姜黄素可调节多个分子靶点，并可应用于临床进行多种治疗过程。有令人信服的证据表明姜黄素可以阻断细胞增殖、侵袭和血管生成，并减少癌细胞的延长存活时间。姜黄素通过下调炎症细胞因子、转录因子、蛋白激酶和促进炎症和慢性疾病发展的酶来介导抗炎作用。此外，姜黄素通过激活半胱天冬酶级联反应，通过线粒体和受体介导的途径诱导细胞凋亡。姜黄素是一种安全无毒的药物，据报道耐受性良好。现有的临床试验支持姜黄素在治疗各种炎症性疾病方面的潜在作用。然而，姜黄素的功效受到吸收差和生物利用度低的阻碍，这限制了其在临床上的应用。本综述概述了姜黄素的潜在药理学和临床作用，