A Pd‐catalyzed three‐component carbonylative‐annulation of 1‐hydroxy‐o‐carborane, internal alkyne and carbon monoxide has been achieved via direct and regioselective cage B−H activation. A class of C,B‐substituted carborano‐coumarin derivatives with potential applications in pharmaceuticals were facilely prepared in moderate to high yields with excellent chemoselectivity and regioselectivity. A plausible reaction mechanism including CO insertion, electrophilic B−H metalation, alkyne insertion and reductive elimination was proposed.

中文翻译：

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通过区域选择性BH活化作用，钯催化1-羟基-o-碳硼烷和内部炔烃的羰基化环化反应。

甲Pd催化的1-羟基的三组分carbonylative成环ø -carborane，内部炔和一氧化碳已经经由直接和区域选择性笼B-H活化实现的。可以容易地以中等到高产率制备具有良好化学选择性和区域选择性的一类可在药物中潜在应用的C，B取代的碳硼烷-香豆素衍生物。提出了可能的反应机理，包括CO插入，亲电BH金属化，炔烃插入和还原消除。