A reprogramming platform: An enzyme‐linked immunosorbent assay (ELISA) using a combination of small‐molecule probes can detect subtle structural changes in the substrate binding pockets of aryl acid adenylation (A) domains. Combined with a directed‐evolution approach, the ELISA technology can be used to isolate aryl acid A‐domains with the desired activity.

中文翻译：

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探索对非核糖体肽合成酶腺苷酸化域重编程的酶联免疫吸附测定的兼容性。

一个重编程平台：结合小分子探针的酶联免疫吸附测定（ELISA）可以检测芳基酸腺苷酸化（A）域底物结合口袋中的细微结构变化。结合定向进化方法，ELISA技术可用于分离具有所需活性的芳酸A结构域。