In this study, the antifungal activity of AgNPs was tested against C. tropicalis (pathogen fungi) and S. boulardii (probiotic). The effectiveness of the AgNPs was assessed by comparing their antifungal activity with a triazole antifungal drug fluconazole and amphotericin B. The AgNPs have a polygonal-like shape (average size of 35 ± 15 nm) with 1.2% wt. of metallic silver stabilized with 18.8% wt. of polyvinylpyrrolidone (PVP) in 80% wt. of distilled water. The results revealed that 35 μg/mL of fluconazole inhibits 55–60% of both fungal cell growth. As for amphotericin B, 5 μg/mL is sufficient to inhibit more than 95% of both fungal cells. For AgNPs, 25 μg/mL was needed to inhibit 90% of the C. tropicalis cell growth, but remarkably, 50% of the S. boulardii cell population remains viable, which can potentiate cell reproduction. Our results could initiate the development of AgNPs possessing selective specificity against pathogenic fungal species.

在这项研究中，测试了AgNPs对热带念珠菌（病原真菌）和布拉氏链球菌（益生菌）的抗真菌活性。通过将它们的抗真菌活性与三唑类抗真菌药氟康唑和两性霉素B进行比较来评估AgNP的有效性。AgNP具有1.2％wt的多边形状形状（平均大小为35±15 nm）。以18.8％wt。聚乙烯吡咯烷酮（PVP）的含量为80％（重量）。蒸馏水。结果表明，35μg/ mL的氟康唑可抑制55-60％的两种真菌细胞生长。对于两性霉素B，5μg/ mL足以抑制超过95％的两种真菌细胞。对于AgNP，抑制25％的热带梭状芽胞杆菌细胞生长需要25μg/ mL ，但值得注意的是，抑制50％猪链球菌仍能存活，可以增强细胞繁殖。我们的结果可能会启动具有针对病原性真菌物种的选择性特异性的AgNPs的开发。