CARD14 is a scaffold molecule predominantly expressed in keratinocytes and genetic variants in the CARD14 gene confer an increased risk of inflammatory skin disease. Due to its association with common skin diseases psoriasis and atopic dermatitis, the biological function of CARD14 is of relevant interest to human health. CARD14 recruits BCL10 and MALT1 to form the CARD-BCL10-MALT1 complex, which modulates NF-κB and MAPK signalling pathways, yet little is known about how CARD14 is regulated or activated in the context of the innate immune response and in chronic inflammation. This review summarises the current understanding of the molecular function and regulatory mechanisms of CARD14 and highlights recent findings in human disease and murine mouse models.

CARD14是主要在角质形成细胞中表达的支架分子，而CARD14基因中的遗传变异会增加炎症性皮肤病的风险。由于其与常见的皮肤病牛皮癣和特应性皮炎有关，因此CARD14的生物学功能与人类健康息息相关。CARD14募集BCL10和MALT1形成CARD-BCL10-MALT1复合物，该复合物调节NF-κB和MAPK信号传导途径，但对于在先天免疫反应和慢性炎症中如何调节或激活CARD14知之甚少。这篇综述总结了对CARD14分子功能和调控机制的当前理解，并着重介绍了人类疾病和鼠类小鼠模型的最新发现。