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Magnetoencephalography resting state connectivity patterns as indicatives of surgical outcome in epilepsy patients.
Journal of Neural Engineering ( IF 4 ) Pub Date : 2020-06-11 , DOI: 10.1088/1741-2552/ab8113
Ümit Aydin 1 , Giovanni Pellegrino , Obaï Bin Ka'b Ali , Chifaou Abdallah , François Dubeau , Jean-Marc Lina , Eliane Kobayashi , Christophe Grova
Affiliation  

Objective. Focal epilepsy is a disorder affecting several brain networks; however, epilepsy surgery usually targets a restricted region, the so-called epileptic focus. There is a growing interest in embedding resting state (RS) connectivity analysis into pre-surgical workup. Approach . In this retrospective study, we analyzed Magnetoencephalography (MEG) long-range RS functional connectivity patterns in patients with drug-resistant focal epilepsy. MEG recorded prior to surgery from seven seizure-free (Engel Ia) and five non seizure-free (Engel III or IV) patients were analyzed (minimum 2-years post-surgical follow-up). MEG segments without any detectable epileptic activity were source localized using wavelet-based Maximum Entropy on the Mean method. Amplitude envelope correlation in the theta (4–8 Hz), alpha (8–13 Hz), and beta (13–26 Hz) bands were used for assessing connectivity. Main results. For seizure-free patients, we found an isolated epileptic netwo...

中文翻译:

脑磁图静息状态连接模式作为癫痫患者手术结局的指标。

目的。局灶性癫痫是一种影响多个大脑网络的疾病。然而,癫痫手术通常针对受限区域,即所谓的癫痫病灶。将静止状态(RS)连接性分析嵌入到手术前检查中的兴趣日益浓厚。方法。在这项回顾性研究中,我们分析了耐药性局灶性癫痫患者的脑磁图(MEG)远程RS功能连接模式。对术前记录的7例无癫痫发作(Engel Ia)和5例非癫痫发作(Engel III或IV)患者的MEG进行了分析(术后至少两年随访)。使用均值方法中基于小波的最大熵对没有任何可检测的癫痫活性的MEG片段进行源定位。θ中的幅度包络相关性(4–8 Hz),alpha(8–13 Hz),和β(13–26 Hz)频段用于评估连接性。主要结果。对于无癫痫发作的患者,我们发现了孤立的癫痫网...
更新日期:2020-06-11
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