Parkinson’s disease (PD) is a neurodegenerative disease characterized by bradykinesia, rigidity, and tremor. Age is the main risk factor. Long noncoding RNAs (lncRNAs) are novel RNA molecules of more than 200 nucleotides in length. They may be involved in the regulation of many pathological processes of PD. PD has a variety of pathophysiological mechanisms, including alpha-synuclein aggregate, mitochondrial dysfunction, oxidative stress, calcium homeostasis, axonal transport, and neuroinflammation. Among these, the impacts of lncRNAs on the pathogenesis and progression of PD need to be highlighted. lncRNAs may serve as putative biomarkers and therapeutic targets for the early diagnosis of PD. This study aimed to investigate the role of lncRNAs in various pathological processes of PD and the specific lncRNAs that might be used as putative diagnostic biomarkers and therapeutic targets of PD.

中文翻译：

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长非编码RNA在帕金森氏病中的作用：假定的生物标志物和治疗目标。

帕金森氏病（PD）是一种神经退行性疾病，其特征是运动迟缓，僵硬和震颤。年龄是主要危险因素。长非编码RNA（lncRNA）是长度超过200个核苷酸的新型RNA分子。它们可能参与PD的许多病理过程的调节。PD具有多种病理生理机制，包括α-突触核蛋白聚集体，线粒体功能障碍，氧化应激，钙稳态，轴突运输和神经炎症。其中，lncRNAs对PD的发病机理和进展的影响需要强调。lncRNA可以作为PD早期诊断的假定生物标志物和治疗靶标。