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An optimized antigen-protein fusion.
Nature Biomedical Engineering ( IF 28.1 ) Pub Date : 2020-06-12 , DOI: 10.1038/s41551-020-0572-3
Pedro Romero 1 , Alena Donda 1 , Jeffrey A Hubbell 2
Affiliation  

The fusion of an immunogenic peptide and the protein transthyretin protects the peptide antigen from proteolytic degradation, optimizes its uptake in local draining lymphatics and reduces its presentation in uninflamed distal lymphoid organs, as shown in mice.

中文翻译:

优化的抗原-蛋白质融合。

免疫原性肽和蛋白运甲状腺素蛋白的融合可保护肽抗原免受蛋白水解降解,优化其在​​局部引流淋巴管中的吸收,并减少其在未发炎的远端淋巴器官中的表达,如小鼠所示。
更新日期:2020-06-12
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