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Deformation Response of Catenated DNA Networks in a Planar Elongational Field
ACS Macro Letters ( IF 5.8 ) Pub Date : 2020-06-12 , DOI: 10.1021/acsmacrolett.0c00360
Beatrice W Soh 1 , Patrick S Doyle 1
Affiliation  

A kinetoplast is a complex catenated DNA network that bears resemblance to a two-dimensional polymeric system. In this work, we use single-molecule experiments to study the transient and steady-state deformation of kinetoplasts in a planar elongational field. We demonstrate that kinetoplasts deform in a stagewise manner and undergo transient deformation at large strains, due to conformational rearrangements from an intermediate metastable state. Kinetoplasts in an elongational field achieve a steady-state deformation that depends on strain rate, akin to the deformation of linear polymers. We do not observe an abrupt transition between the nondeformed and deformed states of a kinetoplast, in contrast to the coil–stretch transition for a linear polymer.

中文翻译:

平面延伸场中链状 DNA 网络的变形响应

动质体是一种复杂的连锁 DNA 网络,与二维聚合物系统相似。在这项工作中,我们使用单分子实验来研究运动体在平面拉伸场中的瞬态和稳态变形。我们证明,由于中间亚稳态的构象重排,运动体以阶段性方式变形并在大应变下经历瞬时变形。拉伸场中的动体可实现取决于应变率的稳态变形,类似于线性聚合物的变形。我们没有观察到动质体的非变形和变形状态之间的突然转变,这与线性聚合物的线圈 - 拉伸转变相反。
更新日期:2020-07-21
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