SARS-CoV-2 remains a significant burden on human health. Several lines of evidence suggest that surveillance of sewage and waste can provide an early warning sign for COVID-19 recurrence in a community. In support, SARS-CoV-2 traces were found in sewage in several countries. With this in mind, it is notable that pests, such as cockroaches, are exposed to pathogenic microbes routinely, yet thrive in polluted environments. Such species have likely developed mechanisms to protect themselves against pathogens. In support, recent studies showed that cockroaches possess potent antibacterial molecules to shield themselves from pathogenic bacteria. Among hundreds of molecules, some contained thiazine groups, imidazoles, chromene derivatives, isoquinoline group, sulfonamides, pyrrole-containing analogs, flavanones, and furanones. Here, we propose that cockroaches are a potential source of antiviral molecules to thwart infections. Because this is an unexploited resource for potential antivirals, we believe that cockroaches offer a unique source for novel bioactive molecule(s) to counter COVID-19 with huge clinical impact worldwide.

中文翻译：

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靶向SARS-CoV-2：抗COVID-19的新型抗病毒化合物来源？

SARS-CoV-2仍然是人类健康的重大负担。有几条证据表明，对污水和废物的监视可以为社区中COVID-19的复发提供预警信号。作为支持，在一些国家的污水中发现了SARS-CoV-2痕迹。考虑到这一点，值得注意的是，害虫（如蟑螂）通常会暴露于病原微生物，但在受污染的环境中却会壮成长。这些物种可能已经开发出保护自己免受病原体侵害的机制。作为支持，最近的研究表明，蟑螂具有有效的抗菌分子，可以保护自己免受致病菌的侵害。在数百个分子中，一些包含噻嗪基，咪唑，色烯衍生物，异喹啉基，磺酰胺，含吡咯的类似物，黄烷酮和呋喃酮。这里，我们认为蟑螂是阻止感染的抗病毒分子的潜在来源。因为这是潜在抗病毒药的未开发资源，所以我们认为蟑螂可提供独特的新型生物活性分子来源来对抗COVID-19，并在全球范围内产生巨大的临床影响。