The development of a modular and diastereodivergent approach to acyclic products bearing two distant stereocenters in a 1,5 relationship is reported. Remarkably, it was accomplished in just three catalytic steps from commercially available alkynes. This sequence generates the desired distant stereocenters efficiently and with high diastereocontrol and a perfect E:Z ratio. The approach was used for a noniterative formal synthesis of the α-tocopherol side chain.

中文翻译：

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无环分子中遥远的立体中心（1,5）的立体选择性制备。

据报道，开发了一种模块化和非对映异构的方法，用于以1,5关系存在两个遥远的立体中心的无环产物。值得注意的是，它仅需三个催化步骤即可从市售炔烃中完成。此序列可高效，高非对数控制和完美的E：Z比生成所需的远处立体中心。该方法用于α-生育酚侧链的非迭代形式合成。