Purpose

State-run newborn screening programs screen nearly all babies born in the United States at the time of delivery. After newborn screening has been completed, some states store the residual dried bloodspots. It is unknown how they have been used to address health disparities–related research.

Methods

In 2017–2018, a scoping review was conducted to evaluate the extent, type, and nature of how residual dried bloodspots. The review included 654 eligible publications, worldwide, published before May 2017. A post hoc analysis of the US-based studies using residual dried bloodspots (n = 192) were analyzed.

Results

There were 32 (16.7%) articles identified that studied a condition of a known health disparity or focused on a key population: 25 studies assessed a disease or condition, 6 expressly enrolled a key population, and 1 study included both (i.e., heart disease and African American/Black).

Conclusion

Excluding 12 studies that researched leukemia or a brain tumor, only 20 studies addressed a known health disparity, with 6 stating a specific aim to address a health disparity. This resource could be used to gain further knowledge about health disparities, but is currently underutilized.

中文翻译：

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美国残留新生儿筛查干血斑在健康差异研究中的有限使用。

目的

国营的新生儿筛查计划几乎对所有在美国出生的婴儿进行筛查。新生儿筛查完成后，一些州会储存残留的干血斑。目前尚不清楚它们如何用于解决与健康差异相关的研究。

方法

在 2017-2018 年，进行了范围审查，以评估残留干血斑的程度、类型和性质。该评价包括 2017 年 5 月之前在全球发表的 654 篇符合条件的出版物。对使用残留干血斑 ( n  = 192)的美国研究进行了事后分析。

结果

有 32 篇 (16.7%) 的文章研究了已知健康差异的情况或关注关键人群：25 篇研究评估了疾病或病症，6 篇明确纳入了关键人群，1 篇研究包括两者（即心脏病和非裔美国人/黑人）。

结论

排除 12 项研究白血病或脑肿瘤的研究，只有 20 项研究解决了已知的健康差异，其中 6 项说明了解决健康差异的具体目标。该资源可用于进一步了解健康差异，但目前未得到充分利用。