New actors in optic neuritis pathogenesis

R. E. Rosenstein

This Editorial highlights a study by Fairless et al. (2020) published in the current issue of the Journal of Neurochemistry, in which the authors investigate the influence of retinal NMDA receptor activity in autoimmune optic neuritis. In an optic neuritis model induced by immunisation with myelin oligodendrocyte glycoprotein (AON), a correlation in the timing of retinal ganglion cell (RGC) loss with alterations in the optic nerve actin cytoskeleton dynamic, and visual dysfunction, is observed. An intravitreal injection of glutamate mimics, and an NMDA receptor antagonist avoids the effect of pre‐clinical AON on visual functions and RGC number, as well as on optic nerve actin cytoskeleton. The increase in calcium levels during the initial stages of AON is prevented by MK‐801. Therefore, the impairment of glutamate neurotoxicity could become a new therapeutic strategy for optic neuritis treatment.

Read the highlighted article on page 693 and the full Editorial Highlight on page 671.

中文翻译：

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发行信息

视神经炎发病机制中的新角色

罗森斯坦

本社论重点介绍了Fairless等人的一项研究。（2020）发表在最新一期的《神经化学杂志》上，作者在其中研究了视网膜NMDA受体活性对自身免疫性视神经炎的影响。在髓鞘少突胶质细胞糖蛋白（AON）免疫诱导的视神经炎模型中，观察到视网膜神经节细胞（RGC）丧失的时机与视神经肌动蛋白细胞骨架动态和视觉功能障碍的相关性。玻璃体内注射谷氨酸模拟物和NMDA受体拮抗剂可避免临床前AON对视觉功能和RGC数目以及视神经肌动蛋白细胞骨架的影响。MK-801可防止AON初期钙水平的升高。因此，

阅读第693页的突出显示的文章和第671页的完整社论集锦。