TTK (also known as Mps1) is the core component of the spindle assembly checkpoint, which ensures proper distribution of chromosomes to daughter cells to maintain genome integrity and to balance growth and division. However, the function of TTK in tumorigenesis has not been extensively studied, especially in relation to the development of gastric cancer. In this study, survival and tumor recurrence data related to TTK expression level in gastric cancer patients were collected and analyzed. We observed that TTK expression was negatively correlated with survival and tumor recurrence in vivo. TTK was also upregulated in gastric cancer cells and was observed to be essential for the proliferation and survival of gastric cancer cells. Knockdown of TTK inhibited proliferation and increased apoptosis. Furthermore, we report that TTK regulates the proliferation and apoptosis of tumor cells through the Akt‐mTOR pathway. Knockdown of TTK inhibited activation of Akt‐mTOR signaling. In summary, our data indicate that TTK is involved in the regulation of gastric cancer proliferation and apoptosis.

中文翻译：

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TTK 通过 Akt-mTOR 通路调节胃癌细胞的增殖和凋亡。

TTK（也称为 Mps1）是纺锤体组装检查点的核心组件，可确保染色体正确分布到子细胞中，以保持基因组完整性并平衡生长和分裂。然而，TTK 在肿瘤发生中的功能尚未得到广泛研究，特别是与胃癌的发展有关。本研究收集并分析与胃癌患者TTK表达水平相关的生存和肿瘤复发数据。我们观察到TTK表达与体内存活和肿瘤复发呈负相关. TTK 在胃癌细胞中也被上调，并被观察到对胃癌细胞的增殖和存活至关重要。敲除 TTK 可抑制增殖并增加细胞凋亡。此外，我们报告说 TTK 通过 Akt-mTOR 通路调节肿瘤细胞的增殖和凋亡。TTK 的敲低抑制了 Akt-mTOR 信号的激活。总之，我们的数据表明TTK参与了胃癌增殖和凋亡的调节。