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Transcriptional meta-analysis of regulatory B cells.
European Journal of Immunology ( IF 5.4 ) Pub Date : 2020-06-11 , DOI: 10.1002/eji.201948489
Florian Dubois 1, 2 , Sophie Limou 1, 3 , Mélanie Chesneau 1, 2 , Nicolas Degauque 1, 2 , Sophie Brouard 1, 2, 4 , Richard Danger 1, 2
Affiliation  

Regulatory B cells (Bregs) have the ability to regulate inflammation in various pathological situations, making them key players in immune regulation. Several mechanisms have been described and we recently identified a GZMB expressing Breg population in kidney transplanted patients who tolerate a kidney graft. To further investigate their biology and mechanisms, we conducted a transcriptomic analysis by RNAseq of these cells and we performed the first weighted meta‐analysis of publicly available transcriptomic data from published Breg studies both in humans and mice. We identified two distinct and unique transcriptional signatures of 126 and 93 genes, respectively, associated with these Bregs. While we highlighted genes coding for proteins with potent involvement in regulatory functions, proliferation, and coding for transcription factors, the comparison between humans and mice did not allow identifying a common pattern. Thus, our results suggest distinct species‐restricted Breg transcriptional signatures in humans and mice.

中文翻译:

转录的荟萃分析调节性B细胞。

调节性B细胞(Bregs)具有在各种病理情况下调节炎症的能力,使其成为免疫调节的关键参与者。已经描述了几种机制,并且我们最近在耐受肾脏移植的肾脏移植患者中发现了表达GZMB的Breg种群。为了进一步研究它们的生物学和机制,我们通过RNAseq对这些细胞进行了转录组分析,并对来自已公开的Breg研究在人和小鼠中公开获得的转录组数据进行了首次加权荟萃分析。我们确定了分别与这些Bregs相关的126和93基因的两个独特的转录特征。尽管我们重点介绍了编码蛋白质的基因,这些基因有效参与调节功能,增殖和编码转录因子,人与小鼠之间的比较无法确定共同的模式。因此,我们的结果表明在人类和小鼠中不同的物种限制Breg转录特征。
更新日期:2020-06-11
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