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Characterization of maitotoxin-4 (MTX4) using electrospray positive mode ionization high-resolution mass spectrometry and UV spectroscopy.
Rapid Communications in Mass Spectrometry ( IF 2 ) Pub Date : 2020-06-12 , DOI: 10.1002/rcm.8859 Francesco Pisapia 1 , Manoëlla Sibat 1 , Ryuichi Watanabe 2 , Catherine Roullier 3 , Toshiyuki Suzuki 2 , Philipp Hess 1 , Christine Herrenknecht 3
Rapid Communications in Mass Spectrometry ( IF 2 ) Pub Date : 2020-06-12 , DOI: 10.1002/rcm.8859 Francesco Pisapia 1 , Manoëlla Sibat 1 , Ryuichi Watanabe 2 , Catherine Roullier 3 , Toshiyuki Suzuki 2 , Philipp Hess 1 , Christine Herrenknecht 3
Affiliation
The dinoflagellate genera Gambierdiscus and Fukuyoa are producers of toxins responsible for Ciguatera Poisoning (CP). Although having very low oral potency, maitotoxins (MTXs) are very toxic following intraperitoneal injection and feeding studies have shown they may accumulate in fish muscle. To date, six MTX congeners have been described but two congeners (MTX2 and MTX4) have not yet been structurally elucidated. The aim of the present study was to further characterize MTX4.
中文翻译:
使用电喷雾正离子高分辨率质谱和紫外光谱表征 maitotoxin-4 (MTX4)。
甲藻属Gambierdiscus和Fukuyoa是导致雪卡毒 (CP) 中毒的毒素生产者。尽管口服效力非常低,但腹腔注射后的麦托毒素 (MTX) 具有很强的毒性,饲养研究表明它们可能会在鱼的肌肉中积聚。迄今为止,已描述了六个 MTX 同源物,但尚未在结构上阐明两个同源物(MTX2 和 MTX4)。本研究的目的是进一步表征 MTX4。
更新日期:2020-06-12
中文翻译:
使用电喷雾正离子高分辨率质谱和紫外光谱表征 maitotoxin-4 (MTX4)。
甲藻属Gambierdiscus和Fukuyoa是导致雪卡毒 (CP) 中毒的毒素生产者。尽管口服效力非常低,但腹腔注射后的麦托毒素 (MTX) 具有很强的毒性,饲养研究表明它们可能会在鱼的肌肉中积聚。迄今为止,已描述了六个 MTX 同源物,但尚未在结构上阐明两个同源物(MTX2 和 MTX4)。本研究的目的是进一步表征 MTX4。