L‐tyrosine is an amino acid, the concentration of which is found to be highly elevated in patients suffering from diabetic foot ulcer (DFU). The latter proves to be fatal when it turns out chronic and may lead to amputation. The conventional clinical diagnostic methods are costly and time consuming, in which case, the condition of patient(s) may deteriorate long before proper treatment commences. Herein, we report the development of smart band‐aid for real time monitoring of L‐tyrosine by employing enzymatic bio‐sensor using α‐MnO₂/tyrosinase. The smart band‐aid was further integrated with portable electronics capable of wireless data transmission to a personal digital assistant, and its tyrosine sensing performance was evaluated. Anodic current was found to vary linearly with the concentrations of L‐tyrosine in the range of 5 nM–500 μM. The developed sensor displayed a limit of detection and sensitivity of 0.71 nM and 0.67 μA/nM/mm² respectively, with a stability of 25 days. The developed sensor was validated using a commercial impedance analyzer. The impedance response was found to be consistent with the cyclic voltammogram obtained and demonstrated to be a linear function of tyrosine concentration. The developed sensing platform combines early diagnosis with connected health technologies, thus, fitting well into modern healthcare needs.

中文翻译：

---

用于集成健康应用的集成电子设备的糖尿病足溃疡监测的电分析传感器

L-酪氨酸是一种氨基酸，在患有糖尿病足溃疡（DFU）的患者中其浓度会很高。事实证明，后者在导致慢性时可能致命，并可能导致截肢。常规的临床诊断方法是昂贵且费时的，在这种情况下，患者的状况可能在开始适当治疗之前很久就恶化了。在此，我们报道的智能创可贴用于实时监控的发展大号通过采用使用α-MnO的酶生物传感器-酪氨酸₂/酪氨酸酶。智能创可贴进一步与可无线传输到个人数字助理的便携式电子设备集成在一起，并评估了其酪氨酸传感性能。发现阳极电流随L酪氨酸浓度在5 nM–500μM范围内线性变化。研发的传感器显示出0.71 nM和0.67μA/ nM / mm ²的检测极限和灵敏度分别具有25天的稳定性。使用商用阻抗分析仪对开发的传感器进行了验证。发现阻抗响应与所获得的循环伏安图一致，并被证明是酪氨酸浓度的线性函数。先进的传感平台将早期诊断与连接的医疗技术相结合，因此非常适合现代医疗保健需求。