Erythrosides A-G, seven undescribed oleanane-type triterpenoid saponins, were isolated from the seeds of Erythrophleum fordii. Their structures with absolute configurations were determined by extensive spectroscopic analysis including one-dimensional [1D] and two-dimensional [2D] nuclear magnetic resonance [NMR], high-resolution electrospray ionization mass spectroscopy [HR-ESI-MS] analysis, and chemical methods. Erythrosides A-G featured a diverse oligosaccharide chain containing 4-6 pentoses or hexoses at C-3 and a monoterpenic acid or a (E)-cinnamic acid unit at the C-21 position. Of particular interest, erythrosides A-C, E and F contained a rare alpha xylose in their sugar chains. The bioassay results indicated that erythrosides A-C showed moderate cytotoxic activities against human lung cancer cell line PC9 with IC50 values of 13.14, 16.67 and 17.59 μM, respectively (the positive control, Taxol, IC50 = 0.60 nM).

中文翻译：

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红花种子中的三萜皂苷及其细胞毒活性

Erythrosides AG 是七种未描述的齐墩果型三萜皂苷，是从 Erythrophleum fordii 的种子中分离出来的。它们的绝对构型结构是通过广泛的光谱分析确定的，包括一维 [1D] 和二维 [2D] 核磁共振 [NMR]、高分辨率电喷雾电离质谱 [HR-ESI-MS] 分析和化学分析。方法。赤藓糖苷 AG 具有多样化的寡糖链，在 C-3 处包含 4-6 个戊糖或己糖，在 C-21 位置包含一个单萜酸或 (E)-肉桂酸单元。特别令人感兴趣的是，赤藓糖苷 AC、E 和 F 在它们的糖链中含有一种罕见的 α 木糖。生物测定结果表明，赤藓糖苷 AC 对人肺癌细胞系 PC9 显示出中等的细胞毒活性，IC50 值为 13.14、16。