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Forecasting memory function in aging: Pattern-completion ability and hippocampal activity relate to visuo-spatial functioning over 25 years
Neurobiology of Aging ( IF 4.2 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.neurobiolaging.2020.06.005
Lars Nyberg 1 , Xenia Grande 2 , Micael Andersson 3 , David Berron 4 , Anders Lundquist 5 , Mikael Stiernstedt 3 , Anders Fjell 6 , Kristine Walhovd 6 , Greger Orädd 7
Affiliation  

Heterogeneity in episodic memory functioning in aging was assessed with a pattern-completion functional magnetic resonance imaging task that required reactivation of well-consolidated face-name memory traces from fragmented (partial) or morphed (noisy) face cues. About half of the examined individuals (N = 101) showed impaired (chance) performance on fragmented faces despite intact performance on complete and morphed faces, and they did not show a pattern-completion response in hippocampus or the examined subfields (CA1, CA23, DGCA4). This apparent pattern-completion deficit could not be explained by differential hippocampal atrophy. Instead, the impaired group displayed lower cortical volumes, accelerated reduction in mini-mental state examination scores, and lower general cognitive function as defined by longitudinal measures of visuospatial functioning and speed-of-processing. In the full sample, inter-individual differences in visuospatial functioning predicted performance on fragmented faces and hippocampal CA23 subfield activity over 25 years. These findings suggest that visuospatial functioning in middle age can forecast pattern-completion deficits in aging.

中文翻译:

预测衰老中的记忆功能:模式完成能力和海马活动与 25 年以上的视觉空间功能有关

使用模式完成功能磁共振成像任务评估衰老过程中情景记忆功能的异质性,该任务需要重新激活来自碎片化(部分)或变形(嘈杂)面部线索的整合良好的面部姓名记忆痕迹。尽管在完整和变形的面孔上表现完好,但大约一半的受检个体(N = 101)在破碎的面孔上表现出受损(机会)的表现,并且他们在海马或检查的亚区(CA1、CA23、 DGCA4)。这种明显的模式完成缺陷不能用不同的海马萎缩来解释。相反,受损组表现出较低的皮层体积,加速了小型精神状态检查分数的降低,和较低的一般认知功能,如视觉空间功能和处理速度的纵向测量所定义。在整个样本中,视觉空间功能的个体间差异预测了 25 年来碎片化面部和海马 CA23 亚区活动的表现。这些发现表明,中年的视觉空间功能可以预测衰老时的模式完成缺陷。
更新日期:2020-10-01
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