In the present strategy, a novel sensor Z2 of naphthalimide derivative was designed, synthesized and used to detect the sensitivity and selection of heparin. Z2 was suitable to detect heparin without obvious interference from counter ions and biomolecules in a wide pH range of 3-10. The mechanism of heparin detected by fluorescent sensor was due to the energy change of molecular from the structure rotation of the sensor. A limit of detection of Z2 sensing heparin was 7.56 ng/mL. Z2 can be used to detect heparin in 0.02% human serum sample.

中文翻译：

---

基于萘二甲酰亚胺衍生物的人体血清荧光传感器检测肝素

在本策略中，设计，合成了新型的萘二甲酰亚胺衍生物传感器Z2并用于检测肝素的敏感性和选择。Z2适用于检测肝素，在3-10的宽pH范围内不受抗衡离子和生物分子的明显干扰。荧光传感器检测到肝素的机理是由于传感器结构旋转引起分子的能量变化。Z2感测肝素的检出限为7.56 ng / mL。Z2可用于检测0.02％人血清样品中的肝素。