OBJECTIVES High frequency oscillations (HFOs) of Somatosensory evoked potentials (SEPs) reflect the activity of thalamo-cortical and cortical neurons from the sensory pathway. Antiepileptic-drugs (AEDs) reduce seizures acting on the balance between excitation and inhibition. We aimed to study the effect of AED mono and polytherapy on SEP-HFO's components. METHODS Twenty-five patients with focal epilepsy were enrolled for the purpose of this study. Patients were divided in 3 groups according to the number of AEDs (1, 2 or 3 AEDs). Patients in group 1 underwent SEP-HFOs recording in drug naïve condition and at 1 month after AED titration. HFOs were compared in duration, amplitude and latency among the three groups. RESULTS The amplitude and duration of late HFOs of the affected hemisphere (AH) are different between groups and inversely correlated with the number of AEDs. In naïve patients monotherapy reverts the asymmetry in totHFOs (total HFOs) duration. CONCLUSION Our results demonstrate that SEP-HFOs are sensitive to the action of AEDs on cortical excitability. This effect seems to affect mainly the cortical component of HFOs in the AH and it is related to the number of AEDs taken. SIGNIFICANCE SEP-HFOs might be a viable tool to probe cortical excitability changes induced by AEDs.

中文翻译：

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抗癫痫药物对体感诱发电位高频振荡的影响

目的 体感诱发电位 (SEP) 的高频振荡 (HFO) 反映了来自感觉通路的丘脑皮质和皮质神经元的活动。抗癫痫药 (AEDs) 减少癫痫发作，作用于兴奋和抑制之间的平衡。我们旨在研究 AED 单药和多药疗法对 SEP-HFO 成分的影响。方法 本研究纳入了 25 名局灶性癫痫患者。根据 AED 的数量（1、2 或 3 个 AED）将患者分为 3 组。第 1 组的患者在未使用药物的情况下和 AED 滴定后 1 个月接受了 SEP-HFO 记录。比较三组 HFOs 的持续时间、幅度和潜伏期。结果 受影响半球（AH）晚期 HFO 的幅度和持续时间在各组之间不同，并且与 AED 的数量呈负相关。在初次治疗的患者中，单药治疗可恢复 totHFO（总 HFO）持续时间的不对称性。结论 我们的结果表明，SEP-HFO 对 AED 对皮质兴奋性的作用很敏感。这种效应似乎主要影响 AH 中 HFO 的皮质成分，并且与服用 AED 的数量有关。意义 SEP-HFOs 可能是探测 AEDs 引起的皮层兴奋性变化的可行工具。这种效应似乎主要影响 AH 中 HFO 的皮质成分，并且与服用 AED 的数量有关。意义 SEP-HFOs 可能是探测 AEDs 引起的皮层兴奋性变化的可行工具。这种效应似乎主要影响 AH 中 HFO 的皮质成分，并且与服用 AED 的数量有关。意义 SEP-HFOs 可能是探测 AEDs 引起的皮层兴奋性变化的可行工具。