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Effects of locus coeruleus activation and inactivation on hippocampal formation theta rhythm in anesthetized rats.
Brain Research Bulletin ( IF 3.8 ) Pub Date : 2020-06-12 , DOI: 10.1016/j.brainresbull.2020.05.017
A Broncel 1 , R Bocian 2 , P Kłos-Wojtczak 1 , J Konopacki 2
Affiliation  

Previously obtained data suggests that noradrenaline (NE) released from the efferent locus coeruleus (LC) endings in hippocampal formation (HPC) may serve as an important modulating signal involved in the pharmacological mechanisms responsible for the production of type 2 theta rhythm in rats. Hence, two distinct hypotheses were tested in the present study: 1/ if the decrease in HPC level of NE is correlated with the desynchronization of HPC field potential, then the inhibition of LC would be expected to abolish HPC type 2 theta rhythm; 2/ if the increase in HPC NE level is correlated with synchronization of HPC field potential, then the stimulation of LC would be expected to produce type 2 theta. The experiments were performed using an experimental model of HPC type 2 theta rhythm recorded in urethanized rats. It was demonstrated that electrical stimulation of LC produced type 2 theta rhythm whereas procaine injection into LC, in contrast, reversibly abolished type 2 theta. The possible relation of type 2 theta rhythm with some disturbances of Alzheimer disease are addressed.



中文翻译:

蓝斑点激活和失活对麻醉大鼠海马形成θ节律的影响。

先前获得的数据表明,从海马形成 (HPC) 中的蓝斑传出轨迹 (LC) 末端释放的去甲肾上腺素 (NE) 可能作为重要的调节信号,参与负责产生大鼠 2 型 theta 节律的药理机制。因此,在本研究中测试了两个不同的假设:1/如果 NE 的 HPC 水平的降低与 HPC 场电位的不同步相关,那么 LC 的抑制将有望消除 HPC 2 型 theta 节律;2/ 如果 HPC NE 水平的增加与 HPC 场电位的同步相关,那么 LC 的刺激预计会产生 2 型 theta。使用在尿烷化大鼠中记录的 HPC 2 型 theta 节律的实验模型进行实验。结果表明,LC 的电刺激产生 2 型 theta 节律,而将普鲁卡因注射到 LC 中,相反,可逆地消除了 2 型 theta。讨论了 2 型 theta 节律与阿尔茨海默病的某些障碍之间的可能关系。

更新日期:2020-07-01
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