Salmonids are poikilotherms, which means that their internal temperature varies with that of water. Water temperature thus controls many of their lifecycle processes and physiological functions, which could influence the mechanisms of absorption, distribution, metabolism and excretion (ADME) of many substances, including perfluorinated alkyl acids (PFAAs). However, the processes governing the fate of PFAAs are still poorly understood in fish. Here we developed a physiologically-based toxicokinetic (PBTK) model for rainbow trout (Oncorhynchus mykiss) to study changes in physiological functions and PFAA ADME at different temperatures. The model was calibrated using experimental data from dietary exposure to perfluorooctane sulfonate at 7 °C and 19 °C. Predictions of PFOS concentrations were globally satisfactory at both temperatures, when accounting for the influence of temperature on growth, ventilation rate, cardiac output, clearances, and absorption rates. Accounting for the influence of temperature on tissue–plasma partition coefficients significantly improved predicted in-organ PFOS concentrations.

鲑鱼是poikilotherms，这意味着它们的内部温度随水的温度而变化。因此，水温控制着它们的许多生命周期过程和生理功能，从而可能影响许多物质（包括全氟烷基酸（PFAA））的吸收，分布，代谢和排泄（ADME）的机制。然而，在鱼类中，关于PFAAs命运的过程仍知之甚少。在这里，我们为虹鳟（Oncorhynchus mykiss）开发了基于生理的毒物动力学（PBTK）模型）研究不同温度下生理功能和PFAA ADME的变化。使用在7°C和19°C下从饮食中摄入全氟辛烷磺酸的实验数据对模型进行校准。当考虑温度对生长，通气率，心输出量，清除率和吸收率的影响时，两种温度下全氟辛烷磺酸浓度的预测总体上令人满意。考虑到温度对组织-血浆分配系数的影响，显着改善了预测的体内PFOS浓度。