当前位置: X-MOL 学术Purinergic Signal. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Regulation of tumor infiltrated innate immune cells by adenosine.
Purinergic Signalling ( IF 3.5 ) Pub Date : 2020-06-12 , DOI: 10.1007/s11302-020-09701-6
Regina Strakhova 1 , Octavia Cadassou 1 , Emeline Cros-Perrial 1 , Lars Petter Jordheim 1
Affiliation  

Cancer has the ability to escape the immune system using different molecular actors. Adenosine is known to be involved in mechanisms which control inflammatory reactions and prevent excessive immune response. This purine nucleoside can be translocated from the cell or produced in the extracellular space by 5′-ectonucleotidases. Once bound to its receptors on the surface of immune effector cells, adenosine activates various molecular pathways, which lead to functional inhibition of the cell or its death. Some tumors are infiltrated by the different cells of immune system but are able to use adenosine as an immunosuppressive molecule and thus inhibit immune anticancer response. This mechanism is well described on adaptive cells, but much less on innate cells. This review outlines major effects of adenosine on innate immune cells, its consequences on cancer progression, and possible ways to block the adenosine-dependent immunosuppressive effect.



中文翻译:

腺苷对肿瘤浸润的先天免疫细胞的调节。

癌症有能力使用不同的分子来逃避免疫系统。已知腺苷参与控制炎症反应和防止过度免疫反应的机制。这种嘌呤核苷可以从细胞转移或通过 5'-外核苷酸酶在细胞外空间产生。一旦与免疫效应细胞表面的受体结合,腺苷就会激活各种分子通路,从而导致细胞功能性抑制或死亡。一些肿瘤被免疫系统的不同细胞浸润,但能够利用腺苷作为免疫抑制分子,从而抑制免疫抗癌反应。这种机制在适应性细胞上得到了很好的描述,但在先天细胞上的描述要少得多。本综述概述了腺苷对先天免疫细胞的主要影响,

更新日期:2020-06-12
down
wechat
bug