Purpose

To explore the dynamic changes and correlation between CT imaging manifestations and cellular immunity of COVID-19.

Materials and methods

This retrospective review analyzed 23 patients with COVID-19, including 13 males and 10 females aged 27–70 years, with an average age of 48 years. Patients were divided into two groups: group A with 11 critical-severe patients, and group B with 12 common-mild patients. Clinical, laboratory, and radiological data were collected and analyzed.

Results

LYM, LYM (%), CD3+, CD4+, and CD8+ decreased, while NEU (%), CRP, and CT scores increased in all patients, WBC in group A increased. In group A, on day 10–12 after disease onset, CT scores and CRP reached the highest point, and day 13–15 LYM, LYM (%) reached the lowest but NEU (%) and WBC reached the highest, CD3+, CD4+ and CD8+ were at the lowest on day 10–15. In group B, on day 7–9, CT scores, NEU (%) and CRP reached the peak, but LYM, LYM (%), CD3+, CD4+ and CD8+ reached the lowest. In all patients, CT scores had a significantly negative correlation with CD3+, CD4+, CD8+, LYM (%), and LYM (p = 0.001, r = − 0.797; p = 0.008, r = − 0.698; p = 0.002, r = − 0.775; p < 0.001, r = − 0.785; p = 0.021, r = − 0.571, respectively), and a significantly positive correlation with WBC and NEU (%) (p < 0.001, r = 0.785; p = 0.003, r = 0.691, respectively).

Conclusion

Dynamic changes of CT manifestations and cellular immunity of patients with COVID-19 were regular and correlation was high between these two parameters.

中文翻译：

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2019新型冠状病毒病CT影像表现与细胞免疫的动态变化规律及相关性研究[J].

目的

探讨COVID-19的CT影像表现与细胞免疫的动态变化及相关性。

材料和方法

本回顾性研究分析了 23 名 COVID-19 患者，其中男性 13 名，女性 10 名，年龄 27-70 岁，平均年龄 48 岁。患者分为两组：A组有11名重症患者，B组有12名普通轻度患者。收集和分析了临床、实验室和放射学数据。

结果

所有患者的LYM、LYM（%）、CD3+、CD4+和CD8+均降低，而NEU（%）、CRP和CT评分均升高，A组WBC升高。A组，发病后第10-12天，CT评分和CRP达到最高点，第13-15天LYM，LYM（%）达到最低，NEU（%）和WBC达到最高，CD3+，CD4+ CD8+ 在第 10-15 天最低。B组第7-9天CT评分、NEU(%)、CRP达到峰值，LYM、LYM(%)、CD3+、CD4+、CD8+最低。在所有患者中，CT 评分与 CD3+、CD4+、CD8+、LYM (%) 和 LYM 呈显着负相关（p  = 0.001，r  = − 0.797；p  = 0.008，r  = − 0.698；p  = 0.002，r  = - 0.775; p < 0.001, r  = − 0.785; p  = 0.021，r  = − 0.571，分别），并且与 WBC 和 NEU (%) 显着正相关（p  < 0.001，r  = 0.785；p  = 0.003，r  = 0.691，分别）。

结论

COVID-19患者的CT表现和细胞免疫的动态变化是有规律的，这两个参数之间的相关性很高。