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Vascularization Strategies for Porous Polyethylene Implants
Tissue Engineering, Part B: Reviews ( IF 6.4 ) Pub Date : 2021-02-15 , DOI: 10.1089/ten.teb.2020.0077
Thomas Später 1 , Michael D Menger 1 , Matthias W Laschke 1
Affiliation  

Porous polyethylene (pPE) is a frequently implanted biomaterial in craniofacial reconstructive surgery. Its rapid vascularization and tissue incorporation are major prerequisites to prevent complications, such as material infection, migration, and extrusion. To achieve this, several sophisticated strategies have been introduced and evaluated during the last 20 years. These include (i) the angiogenic stimulation of the host tissue with epidermal growth factor, basic fibroblast growth factor or macrophage-activating lipopeptide-2, (ii) material modifications, such as increase of surface roughness and incorporation of bioactive glass particles, (iii) surface coatings with growth factors, glycoproteins, acrylic acid, arginine/glycine/aspartic acid peptide as well as components of the plasminogen activation system and autologous clotted blood or serum, and (iv) the seeding with fibroblasts, chondrocytes, stem cells, or adipose-tissue-derived microvascular fragments. The majority of these approaches showed promising results in experimental studies and, thus, may be capable of improving the success rates after pPE implantation in future clinical practice.

中文翻译:

多孔聚乙烯植入物的血管化策略

多孔聚乙烯 (pPE) 是颅面重建手术中经常植入的生物材料。其快速血管化和组织结合是预防并发症的主要先决条件,如材料感染、迁移和挤压。为实现这一目标,在过去 20 年中引入并评估了几种复杂的策略。这些包括 (i) 用表皮生长因子、碱性成纤维细胞生长因子或巨噬细胞激活脂肽 2 对宿主组织的血管生成刺激,(ii) 材料修饰,例如增加表面粗糙度和掺入生物活性玻璃颗粒,(iii) ) 具有生长因子、糖蛋白、丙烯酸、精氨酸/甘氨酸/天冬氨酸肽以及纤溶酶原激活系统和自体凝血或血清成分的表面涂层,(iv) 接种成纤维细胞、软骨细胞、干细胞或脂肪组织来源的微血管碎片。大多数这些方法在实验研究中显示出有希望的结果,因此可能能够在未来的临床实践中提高 pPE 植入后的成功率。
更新日期:2021-02-23
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