Background: Breast cancer (BC) is a common tumor in women worldwide, and irradiation (IR) resistance is a major obstacle for BC therapy. Circle RNAs (circRNAs) were identified as implicated in the progression of cancer and IR resistance. However, the role of circABCB10 in BC progression and IR resistance is not well defined.

中文翻译：

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Circle RNA circABCB10 调节 PFN2 以促进乳腺癌进展，并通过促进 miR-223-3p 的糖酵解代谢来加重放射抗性

背景：乳腺癌 (BC) 是全球女性常见的肿瘤，辐射 (IR) 耐药性是 BC 治疗的主要障碍。环状 RNA（circRNA）被确定与癌症和 IR 抗性的进展有关。然而，circABCB10 在 BC 进展和 IR 抗性中的作用尚未明确。