Eutectic solvents (ESs) have shown stabilizing effects on several molecules. Due to the potential applicability of bioactive compounds, understanding how ESs stabilize them is of great interest in pharmaceutical and related fields. Here, among various ESs, CTU, which comprise thiourea and choline chloride (ChCl), exerted remarkably high stabilizing effects on various phenolic compounds, whereas CU consisting of urea and ChCl exhibited the opposite effects. Using a potent polyphenol, (−)-epigallocatechin gallate (EGCG), as a model compound, we conducted experimental and in silico studies to unravel the underlying mechanisms of the two very similar ESs for the contrasting effects. The results suggest that ESs can affect with great diversity the stability of EGCG by complicated interactions arising from the unique properties of both ESs and their components.

中文翻译：

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对共晶溶剂对酚类化合物稳定性的巨大不同影响的见解。

共晶溶剂（ESs）对几种分子表现出稳定作用。由于生物活性化合物的潜在适用性，因此了解ES如何稳定它们在制药及相关领域具有极大的意义。在此，在各种ES中，包含硫脲和氯化胆碱（ChCl）的CTU对各种酚类化合物具有显着高的稳定作用，而由尿素和ChCl组成的CU则表现出相反的作用。我们使用强效多酚（-）-表没食子儿茶素没食子酸酯（EGCG）作为模型化合物，进行了实验和计算机模拟进行研究以揭示两个非常相似的ES的潜在作用机理。结果表明，ESs可以通过ESs及其组件的独特特性引起的复杂相互作用极大地影响EGCG的稳定性。