Herein reported are results of the chemical and biological investigation of red propolis collected at the Brazilian Northeast coastline. New propolones A–D (1–4), with a 3-{3-[(2-phenylbenzofuran-3-yl)methyl]phenyl}chromane skeleton; propolonones A–C (5–7), with a 3-[3-(3-benzylbenzofuran-2-yl)phenyl]chromane skeleton; and propolol A (8), with a 6-(3-benzylbenzofuran-2-yl)-3-phenylchromane skeleton, were isolated as constituents of Brazilian red propolis by cytotoxicity-guided assays and structurally identified by analysis of their spectroscopic data. Propolone B (2) and propolonone A (5) display significant cytotoxic activities against an ovarian cancer cell line expressing a multiple drug resistance phenotype when compared with doxorubicin.

中文翻译：

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从巴西红蜂胶中分离的抗增殖类黄酮二聚体。

本文报告了在巴西东北海岸线采集的红蜂胶的化学和生物学研究结果。具有 3-{3-[(2-苯基苯并呋喃-3-基)甲基]苯基}色烷骨架的新型丙泊酮 A–D ( 1 – 4 )；丙醇酮 A–C ( 5 – 7 )，具有 3-[3-(3-苄基苯并呋喃-2-基)苯基]色烷骨架；和具有 6-(3-苄基苯并呋喃-2-基)-3-苯基色烷骨架的丙泊醇 A ( 8 ) 通过细胞毒性引导分析被分离为巴西红蜂胶的成分，并通过分析它们的光谱数据进行结构鉴定。Propolone B ( 2 ) 和 propolone A ( 5 )) 与多柔比星相比，对表达多重耐药表型的卵巢癌细胞系显示出显着的细胞毒活性。