The addition amount and dispersion of inorganic particles into poly(lactic acid) (PLA) still remain a great difficulty, and in the present study, epoxidized soybean oil was used to improve the compatibility between hydroxyapatite (HA) and PLA via the melt blending method. Scanning electron microscopy shows that HA particles can be well dispersed in the PLA matrix when the addition amount is less than 20% in mass, whereas the agglomeration of HA particles and a discrete phase of PLA could be observed when the amount increases to 30%. Therefore, the maximum amount of HA particles can be achieved for the composite with 20% HA which can be also maintaining the bending strength of 71.6 MPa. The osteoblast cells were used to characterize the biocompatibility of the HA/PLA composite, and the results indicate that the number of cells in per unit volume cultured on the HA/PLA composite is 10% higher than that of the PLA. Based on the improved cell biocompatibility and mechanical strength compared to PLA, the composite of HA/PLA prepared in the present study can be served as a potential candidate for the bone fracture repair.

无机颗粒在聚乳酸（PLA）中的添加量和分散性仍然很困难，在本研究中，环氧化大豆油被用来改善羟基磷灰石（HA）与聚乳酸之间的相容性。熔体混合法。扫描电子显微镜显示，当添加量小于20质量％时，HA颗粒可以很好地分散在PLA基质中，而当添加量增加到30％时，可以观察到HA颗粒的团聚和PLA的离散相。因此，对于具有20％HA的复合材料，可以实现HA颗粒的最大量，其还可以保持71.6MPa的弯曲强度。成骨细胞用于表征HA / PLA复合材料的生物相容性，结果表明，在HA / PLA复合材料上培养的每单位体积的细胞数比PLA高10％。与PLA相比，基于改善的细胞生物相容性和机械强度，