A stereodivergent preparation of cis and trans 4‐aminopipecolic acids (4‐APAs) was developed from a common precursor to obtain suitably protected, constrained γ‐amino acids useful in peptidomimetic synthesis. Two antagonists of α_Vβ₃ integrin were synthesized.

中文翻译：

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对映体合成顺式和反式4-氨基哌酸作为γ-氨基酸，用于构建含环RGD的拟肽类αVβ3整联蛋白拮抗剂。

从常见的前体中开发出了顺式和反式4-氨基哌酸（4-APA）的立体发散剂，以获得可适当保护，受约束的γ-氨基酸，可用于拟肽合成。α的两个拮抗剂_V β ₃整联合成。