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MAFB modulates the maturation of lymphatic vascular networks in mice.
Developmental Dynamics ( IF 2.5 ) Pub Date : 2020-06-11 , DOI: 10.1002/dvdy.209
Maria Rondon-Galeano 1, 2 , Renae Skoczylas 1, 3 , Neil I Bower 1 , Cas Simons 1, 4 , Emma Gordon 1 , Mathias Francois 1, 5 , Katarzyna Koltowska 1, 3 , Benjamin M Hogan 1, 2, 6
Affiliation  

Lymphatic vessels play key roles in tissue fluid homeostasis, immune cell trafficking and in diverse disease settings. Lymphangiogenesis requires lymphatic endothelial cell (LEC) differentiation, proliferation, migration, and co‐ordinated network formation, yet the transcriptional regulators underpinning these processes remain to be fully understood. The transcription factor MAFB was recently identified as essential for lymphangiogenesis in zebrafish and in cultured human LECs. MAFB is activated in response to VEGFC‐VEGFR3 signaling and acts as a downstream effector. However, it remains unclear if the role of MAFB in lymphatic development is conserved in the mammalian embryo.

中文翻译:

MAFB 调节小鼠淋巴管网络的成熟。

淋巴管在组织液稳态、免疫细胞运输和各种疾病环境中起着关键作用。淋巴管生成需要淋巴管内皮细胞 (LEC) 分化、增殖、迁移和协调的网络形成,但支持这些过程的转录调节因子仍有待充分了解。转录因子 MAFB 最近被确定为斑马鱼和培养的人类 LEC 淋巴管生成所必需的。MAFB 响应 VEGFC-VEGFR3 信号传导而被激活,并充当下游效应器。然而,目前尚不清楚 MAFB 在淋巴发育中的作用是否在哺乳动物胚胎中是保守的。
更新日期:2020-06-11
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