The purpose of this study was to examine the possible inverse relationship between total meat intake and processed meat intake and insulin sensitivity as mediated by body mass index (BMI). The Quantitative Insulin Sensitivity Check Index (QUICKI) was used to assess participants' insulin sensitivity: decreased insulin sensitivity indicated at a score of <0.36. Cross-sectional data were used from Visit 1 of the Atherosclerosis Risk in Communities (ARIC) cohort. Mediation analysis was conducted using the PROCESS macro for SPSS. The mean BMI was 27.3 ± 5.0 kg/m2, total meat intake was 1.76 ± 0.89 servings per day, processed meat intake was 0.44 ± 0.46 servings per day, and the mean QUICKI score was 0.34 ± 0.039. This suggested decreased insulin sensitivity was prevalent in this population. As hypothesized and previously shown, both total meat intake and processed meat were inversely and significantly associated with insulin sensitivity after adjusting for key covariates including BMI. In mediation analysis, the significant inverse direct association model between total meat and QUICKI was -0.0017 (95% CI: -0.0026, -0.0008). BMI had a significant indirect association with QUICKI of -0.0028 (95% CI: -0.0033, -0.0023) which accounted for 62% of the association between total meat intake and insulin sensitivity. In the processed meat intake and QUICKI mediation model, BMI accounted for a significant 43% of the relationship. Our results suggest that the association between total meat and processed meat intake and insulin sensitivity is mediated by BMI.

中文翻译：

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体重指数介导肉类摄入量与胰岛素敏感性之间的关联

本研究的目的是检查总肉类摄入量和加工肉类摄入量与由体重指数 (BMI) 介导的胰岛素敏感性之间可能的反比关系。定量胰岛素敏感性检查指数 (QUICKI) 用于评估参与者的胰岛素敏感性：评分 <0.36 表示胰岛素敏感性降低。横断面数据来自社区动脉粥样硬化风险 (ARIC) 队列的第 1 次访问。中介分析是使用 SPSS 的 PROCESS 宏进行的。平均 BMI 为 27.3 ± 5.0 kg/m2，总肉类摄入量为每天 1.76 ± 0.89 份，加工肉摄入量为每天 0.44 ± 0.46 份，平均 QUICKI 得分为 0.34 ± 0.039。这表明胰岛素敏感性降低在该人群中普遍存在。正如假设和先前所示，在调整包括 BMI 在内的关键协变量后，总肉类摄入量和加工肉类均与胰岛素敏感性呈负相关且显着相关。在中介分析中，总肉类与 QUICKI 之间的显着负直接关联模型为 -0.0017（95% CI：-0.0026，-0.0008）。BMI 与 QUICKI 之间的显着间接关联为 -0.0028（95% CI：-0.0033，-0.0023），占总肉类摄入量与胰岛素敏感性之间关联的 62%。在加工肉类摄入量和 QUICKI 中介模型中，BMI 占关系的 43%。我们的结果表明，总肉类和加工肉类摄入量与胰岛素敏感性之间的关联是由 BMI 介导的。