Self-assembly of amphiphilic polymers into micelles in dialysis process is dynamic, and the phase transition process is therefore very challenging to observe experimentally. In this study, we built a dynamic modeling by applying dissipative particle dynamics (DPD) simulations to explore the entire micelle formation process during the dynamic. The self-assembled aggregates undergo four stages in the process of dialysis: (i) Dispersed stage, (ii) Pre-micellar stage, (iii) Over-micellar stage. (iv) The final micellar stage. The study thus provides great advantages in simulating the processing dynamics of drug delivery systems, which would further expand the application scope of DPD simulations.

两亲性聚合物在透析过程中自组装成胶束是动态的，因此相变过程在实验上很难观察。在这项研究中，我们通过应用耗散粒子动力学（DPD）模拟来建立动态模型，以探索动力学过程中的整个胶束形成过程。自组装聚集体在透析过程中经历四个阶段：（i）分散阶段，（ii）胶束前阶段，（iii）胶束过阶段。（iv）最后的胶束阶段。因此，该研究在模拟药物输送系统的处理动力学方面具有很大的优势，这将进一步扩大DPD模拟的应用范围。