The facile fabrication of covalent organic frameworks (COFs) is significant for exploring and promoting their application. In this study, TAPA-TFPB-COFs with flower-shaped morphology, good crystallinity, and high surface area was prepared via a facile room-temperature method. The as-synthesized TAPA-TFPB-COFs exhibited great adsorption capacity towards quinolone antibiotics (QAs) and satisfying reusability. Utilizing the TAPA-TFPB-COFs as solid-phase extraction cartridge packing and liquid chromatography-tandem mass spectrometry as detector, a reliable and ultrasensitive method for the assay of QAs was developed. The linearity ranges of QAs extended from 0.5 to 200 ng L-1 with correlation coefficients higher than 0.9974, and the limits of detection varied from 0.02 to 0.11 ng L-1. The intra-day and inter-day precision were lower than 10.8% and 6.7%, respectively. The applicability of the developed method was evaluated through analyzing of tap water, spring water, chicken, and fish samples. The recoveries of QAs in spiked water and food samples varied from 80.0% to 107.6%. The reliability of the developed method was further verified by the accurate detection of QAs in a fish certified reference material.

中文翻译：

---

用于固相萃取喹诺酮类抗生素的花形共价有机骨架的室温合成

共价有机框架（COFs）的简便制造对于探索和促进其应用具有重要意义。在这项研究中，通过简便的室温方法制备了具有花形形态、良好结晶度和高表面积的 TAPA-TFPB-COFs。合成的 TAPA-TFPB-COFs 对喹诺酮类抗生素 (QAs) 表现出很强的吸附能力和令人满意的可重复使用性。以TAPA-TFPB-COFs作为固相萃取柱填料，液相色谱-串联质谱作为检测器，开发了一种可靠且超灵敏的QAs测定方法。QA 的线性范围从 0.5 到 200 ng L-1，相关系数高于 0.9974，检测限从 0.02 到 0.11 ng L-1。日内和日间精密度均低于 10.8% 和 6。分别为 7%。通过对自来水、泉水、鸡肉和鱼类样品的分析，评估了所开发方法的适用性。加标水和食品样品中 QA 的回收率从 80.0% 到 107.6% 不等。通过准确检测鱼类认证标准物质中的质量保证，进一步验证了所开发方法的可靠性。